During the last few decades, Raman spectroscopy has become a widely used, viable technique in the pharmaceutical industry. This is best illustrated by the diverse and steadily increasing number of different pharmaceutical Raman applications. Raman instruments have become ‘‘standard kits’’ in the industry. Raman technique has been used in drug development phase as well as in production phase to ensure drug quality. After the production phase, this technique can be used to verify the uniformity of solid and liquid formulations, to study the product shelf life, and to ensure the authenticity of the drugs.

Raman Spectroscopic Applications in Pharmaceutical industry

Drug development / API Production Drug Production Analysis of Drugs
  • Crystallization monitoring
  • Polymorphic form identification
  • On-line reaction monitoring and optimization
  • End-point and intermediate detection
  • Hydrate/solvate and salt detection and identification
  • Identification and verification of raw materials
  • Monitoring different unit operation processes such as granulation, blending and coating
  • Contaminant identification and cleaning verification
  • Non-destructive solid and liquid formulation analysis
  • Product shelf life verification
  • Product authentification

Timegated® advantages to (bio)pharmaceuticals

• Effective luminescence (fluorescence) suppression to strong fluorescent backgrounds
• Potential to biopharmaceutical e.g. in vitro cell studies where the most Raman techniques suffer from strong luminescence (fluorescence) background

Some scientific evidence of the TimeGate advantages in (bio) pharmaceuticals is available in Analytical and Bioanalytical Chemistry Research Paper: Fluorescence-suppressed time-resolved Raman spectroscopy of pharmaceuticals using complementary metal-oxide semiconductor (CMOS) single-photon avalanche diode (SPAD) detector. Open access paper can be accessed at SpringerLink